Aquatic Litter is a major cross-border issue with environmental, social, and economic implications. The modern way of life that leads to uncontrolled consumption, as well as the long-term improper management of waste, has made aquatic litter one of the major environmental issues in the world. In order to deal with it, it is imperative to change the mentality and to make and implement correct political decisions immediately. iSea through its projects focuses on the investigation of the composition and distribution of waste along the coasts and seabeds of Greece, but also on interventions for the reduction and proper management of waste. An additional purpose is to inform and raise awareness of target groups for their active involvement in addressing the issue, as well as the adoption of good practices to reduce their waste.